Beriplex Cardio

Beriplex® indication: For the treatment and perioperative prophylaxis of bleedings in acquired deficiency of the prothrombin complex coagulation factors, when rapid correction of the deficiency is required.1

4F-PCC Body of evidence (Selection of leading publications)
Over 12,000 cardiac surgery patients studied over past 15 years1–12

Beriplex - Evidence & Observational studies

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DISCLAIMER: This material includes data from global studies, where the 4-factor prothrombin complex concentrate (4F-PCC) used may come from multiple sources and manufacturers using different processes. In Australia, the only 4F-PCC product is BERIPLEX®. BERIPLEX AU® is derived from plasma from Australian donors.

Resources and information on human prothrombin complex product Beriplex®

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Product information

View the Approved Product Information for Beriplex®

References: 1. BERIPLEX® Approved Product Information. 2. Görlinger K, et al. Anesthesiology. 2011;115(6):1179-1191. 3. Arnékian V, et al. Interact Cardiovasc Thorac Surg. 2012;15(3):382-389. 4. Cappabianca G, et al. Crit Care. 2016;20: 5. Mehringer SL, et al. Ann Pharmacother. 2018;52(6):533-537. 6. Fitzgerald J, et al. Br J Anaesth. 2018;120(5):928-934. 7. Roman M, et al. Ann Thorac Surg. 2019;107(4):1275-1283. 8. Hayes K, et al. Cochrane Database Syst Rev. 2022;11(11):CD013551. 9. Viana P, et al. J Chest Surg. 2024;57(1):25-35. 10. Karkouti K, et al. JAMA Netw Open. 2021;4(4):e213936. 11. Green L, et al. Anaesthesia. 2021;76(7):892-901. 12. Smith MM, et al. JAMA Surg. 2022;157(9):757-764. Beriplex® is a registered trade mark of CSL Limited.

For information: CSL Behring (Australia) Pty Ltd: For Medical/Technical Inquiries: Phone: 1800 642 865. For Customer Service Inquiries: Phone: 1800 063 892. E-mail: customerservice@cslbehring.com.au. Internet: www.cslbehring.com.au. CSL Behring (Australia) Pty Ltd 655 Elizabeth Street, Melbourne, Vic, 3000. ABN: 48 160 734 761. August 2025. AU-BAU-0067. 2961.

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